Review finds liraglutide added to insulin improves glycemic control in cardiac surgery
Three randomized trials totaling 168 patients with type 2 diabetes showed lower glucose and less variability, but more nausea and vomiting with liraglutide.
MH
By Maren Holt · Senior Reporter, GLP-1
Sep 30 20:00 ETSource: Annals of cardiac anaesthesia
The wire
- 01A systematic review in Annals of Cardiac Anaesthesia pooled three RCTs of 168 patients, finding subcutaneous liraglutide 0.6-1.8 mg/day alongside insulin lowered perioperative glucose with low hypoglycemia incidence.
- 02Perioperative GLP-1 use remains contested; the data give anesthesiologists and surgical teams preliminary support for adjunct liraglutide rather than insulin alone in diabetic cardiac surgery patients.
- 03Authors caution that dosing, timing and monitoring protocols varied widely across the three small studies, with no long-term outcome data; larger standardized trials are needed.
From the source
Read at pubmed.ncbi.nlm.nih.govGLP-1 Receptor Agonists and Insulin Versus Insulin for Perioperative Glycemic Control in Patients with Type 2 Diabetes Undergoing Cardiac Surgery: A Systematic Review
Annals of cardiac anaesthesia · 2026 Oct 1 · Hassan D, Shakeel R, Qaisi W et al.
Source URL https://pubmed.ncbi.nlm.nih.gov/42862661/
