Pathologists report histologic case of tirzepatide-linked pneumatosis intestinalis

The wire

1. 01In the American Journal of Clinical Pathology, authors describe what they call the first documented histologic diagnosis of possible tirzepatide-associated pneumatosis intestinalis, found on colon biopsy during colonoscopy for abdominal pain and constipation.
2. 02Clinicians managing incretin patients with persistent GI complaints now have described histologic features, including foreign body-type giant cell reactions and eosinophil- and neutrophil-rich infiltrates, to aid recognition.
3. 03This is a single case report in a patient with obesity, type 2 diabetes, hypertension and sleep apnea who had lost 49 pounds; causation is not established and the authors call for further reporting.

From the source

Tirzepatide-induced pneumatosis intestinalis: a rare but clinically significant gastrointestinal adverse effect

American journal of clinical pathology · 2026 Oct 10 · Kassardjian A, Shafizadeh N et al.