Meta-analysis finds no clear handgrip strength change with semaglutide
Pooled within-group data from 660 treated adults showed a 0.16 kgf decline that was not statistically significant, with very low certainty evidence.
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By Maren Holt · Senior Reporter, GLP-1
Oct 18 20:00 ETSource: Diabetes, obesity & metabolism
The wire
- 01A PRISMA systematic review of 11 studies pooled uncontrolled within-group handgrip changes in 660 semaglutide-treated adults, finding -0.16 kgf (95% CI -1.98 to 1.65) and I-squared of 90.8%.
- 02Clinicians fielding questions about muscle loss on semaglutide have no firm answer: the authors say the data neither establish strength preservation nor a causal treatment effect.
- 03Duration-stratified and sensitivity analyses were also nonsignificant; only one small randomized trial measured knee extension, and the authors call for controlled studies with standardized strength testing.
From the source
Read at pubmed.ncbi.nlm.nih.govChanges in Muscle Strength Following Semaglutide Treatment in Adults: A Systematic Review With Meta-Analysis of Handgrip Strength
Diabetes, obesity & metabolism · 2026 Oct 19 · Machado LG, Siedschlag Schmidt PH, Tasca Petroski G et al.
Source URL https://pubmed.ncbi.nlm.nih.gov/42897109/
