Case report describes semaglutide stopped after antipsychotic weight gain reversed

The wire

1. 01A single adolescent case in Hormone Research in Paediatrics: semaglutide normalized BMI and hemoglobin A1c after aripiprazole-induced weight gain, then was discontinued with weight maintained over six months.
2. 02Pediatric clinicians managing antipsychotic-induced weight gain currently lean on metformin, which the authors call modestly effective; the report raises GLP-1 agonists as possible temporary bridge therapy.
3. 03The authors call the observation hypothesis-generating only, citing confounding factors, and say larger prospective studies are needed before any broader clinical use.

From the source

Weight Maintenance Following Discontinuation of Semaglutide in an Adolescent with Antipsychotic-Associated Weight Gain: A Case Report

Hormone research in paediatrics · 2026 Oct 12 · Griffing E, Dabrowski E et al.