Researchsemaglutidemicroneedlesobesitydrug-delivery

Dissolving microneedle patch delivers semaglutide through skin in obese rats

Each PVA patch held 29 micrograms of semaglutide and delivered about 63% of it, cutting food intake and weight over seven days.

By Priya Raman · Science Reporter

Oct 20 20:00 ETSource: International journal of pharmaceutics

The wire

01Researchers built 15 by 15 arrays of poly(vinyl alcohol) dissolving microneedles that penetrated rat skin, partly dissolved within five minutes and released over 90% of labelled cargo in 30 minutes.
02Once-daily patches for seven days in high-fat-diet obese rats reduced food intake, body weight, adipocyte size and hepatic lipid, and improved glucose tolerance.
03This is an early rat feasibility study with microgram-level dosing far below human therapeutic exposure; no human pharmacokinetic or tolerability data exist.

From the source

Poly(vinyl alcohol) dissolving microneedles for transdermal semaglutide delivery and anti-obesity therapy in rats
International journal of pharmaceutics · 2026 Oct 21 · Cheng X, Wang F, Liu H et al.

Read at pubmed.ncbi.nlm.nih.gov

Source URL https://pubmed.ncbi.nlm.nih.gov/42906796/