Machine-learning peptide CIT8 kills carbapenem-resistant A. baumannii in lab tests
The 13-residue frog-skin-derived peptide also disrupted biofilms and increased meropenem's bactericidal activity with low toxicity to human cells, researchers report.
PR
By Priya Raman · Science Reporter
Oct 19 06:22 ETSource: Bioengineer.org
The wire
- 01Researchers describe CIT8, a machine learning-optimized 13-residue peptide derived from frog skin, that rapidly killed carbapenem-resistant Acinetobacter baumannii and dismantled biofilms in laboratory testing.
- 02Antimicrobial peptide candidates are one route being pursued against Gram-negative resistance, a space readers tracking LL-37 and related work follow.
- 03Results are preclinical; no animal efficacy, pharmacokinetic or human safety data are reported in the summary.
From the source
Read at bioengineer.orgMachine Learning-Designed Peptide CIT8 Wipes Out Carbapenem-Resistant Superbug in Minutes
A machine learning-optimized 13-residue peptide derived from frog skin rapidly kills carbapenem-resistant Acinetobacter baumannii, dismantles biofilms, and boosts meropenem's bactericidal activity with low toxicity to human cells.
