Researchelamipretidess-31ovarian agingfertilitymitochondria

Elamipretide raises litter size and oocyte quality in aged mice

The mitochondrial peptide also improved maturation, fertilization and cleavage of aged human oocytes in culture, the Aging Cell authors report.

By Priya Raman · Science Reporter

Sep 30 20:00 ETSource: Aging cell

The wire

01Researchers report elamipretide injection increased litter size in aged mice and restored nuclear and cytoplasmic maturation of aged oocytes, acting through a vitamin B6-VEGF axis.
02Elamipretide (SS-31) is tracked closely by readers following mitochondrial and longevity peptides; this extends its claimed effects into reproductive aging.
03Findings rest on mouse, porcine and ex vivo human oocyte work with no clinical dosing data, so no fertility use in people is supported yet.

From the source

Elamipretide Rejuvenates Oocyte Quality and Restores Female Fertility During Reproductive Aging
Aging cell · 2026 Oct · Zhang HL, Wang Y, Wang C et al.

Read at pubmed.ncbi.nlm.nih.gov

Source URL https://pubmed.ncbi.nlm.nih.gov/42827331/