Self-assembling peptide recruits antibodies to EGFR-positive tumor cells
Receptor binding converts monomeric hapten conjugates into multivalent fibrils on the cell surface, triggering complement-mediated killing with what researchers describe as minimal toxicity.
PR
By Priya Raman · Science Reporter
Oct 5 03:16 ETSource: Bioengineer.org
The wire
- 01Researchers report a receptor-triggered peptide self-assembly strategy that builds antibody-recruiting fibrils on EGFR-positive tumor cells, driving complement-mediated cell killing.
- 02The design shows how short peptides can be used as surface-assembling immune adaptors rather than conventional binders, a mechanism relevant to peptide drug designers.
- 03Reported results are preclinical and the summary gives no animal efficacy, dose or safety data, so translational value is unestablished.
From the source
Read at bioengineer.orgSelf-Assembling Peptide Turns Tumor Cells Into Antibody Magnets for Cancer Immunotherapy
A receptor-triggered peptide self-assembly strategy converts monomeric hapten conjugates into multivalent antibody-recruiting fibrils on EGFR-positive tumor cells, driving potent complement-mediated cancer cell killing with minimal toxicity.
