Synthetic peptide P33 cuts brain amyloid 35.6% in Alzheimer's mice

The wire

1. 01Screening a library of 50 modified peptides in cultured mouse neurons, researchers found P33 halved amyloid beta release and cut BACE1-associated activity by more than 50% without affecting BACE2.
2. 02Eight weeks of P33 in amyloid-plaque mice reduced brain amyloid beta and cortical and hippocampal plaque area by 35.6%, with no organ damage or inflammation marker changes reported.
3. 03Results are confined to cell cultures and a transgenic mouse model, published in Bioorganic Chemistry; no human dosing, pharmacokinetic or safety data exist yet.

From the source

Peptide Cut Brain Amyloid Plaques by More Than One-Third in Preclinical Study

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