Rat preprint reports semaglutide blunts cue-induced cocaine seeking

The wire

1. 01In the bioRxiv preprint, rats that self-administered cocaine received daily semaglutide across 30 days of abstinence before cue- and cocaine-induced reinstatement testing.
2. 02Adds to the preclinical case for GLP-1 agonists in substance use disorders, a question clinicians increasingly field alongside off-label alcohol use.
3. 03This is an unreviewed animal preprint; operant responding rose after cocaine priming, and no human cocaine use disorder data are reported.

From the source

Chronic semaglutide treatment attenuates cue-induced reinstatement of cocaine-seeking and cocaine-induced stereotypy in male and female rats

bioRxiv : the preprint server for biology · 2026 Sep 28 · Turner CA, Morales Pagán N, Pereira D et al.