Semaglutide cuts chemotaxis and egg-laying in C. elegans, study reports

The wire

1. 01In microPublication Biology, wild-type N2 C. elegans exposed to semaglutide at 1 uM and 10 uM showed significantly reduced chemotaxis toward the odorant diacetyl, along with reduced egg-laying and delayed larval development.
2. 02The authors argue the worm offers a tractable model for dissecting GLP-1 receptor agonist mechanisms at cellular resolution, relevant to appetite and reward circuitry questions.
3. 03This is an invertebrate model with no annotated GLP-1 receptor orthologue discussed here, so the findings do not translate to human dosing or reproductive effects.

From the source

Semaglutide Reduces Odorant-Driven Chemotaxis and Reproductive Output in Caenorhabditis elegans

microPublication biology · 2026 · Kousnetzov S, Rodriguez ACI, Lopez RB et al.